Pharmacosomes as Unique and Potential Drug Delivery System
DOI:
https://doi.org/10.5281/Keywords:
Pharmacosomes, Drug Delivery SystemAbstract
Many phospholipid-based formulations are successfully used as drug delivery systems which deliver the drug at the site of action. Pharmacosomes are one of the unique and potential vesicular systems which contain drug-phospholipid conjugates that are more stable compared to other novel approaches. There are many pharmaceutical agents such as proteins, peptides, nucleic acids, anticancer drugs, antihypertensive drugs, and other agents that have less bioavailability, low solubility and permeability profiles, rapid clearance, high GI toxicity, and rapid elimination from the body, resulting in adverse effects. Therefore, there are enormous requirements to develop drug delivery methods and carriers that will provide essential and effective delivery for such therapeutic agents or drug molecules. One of the promising novel approaches to promote the absorption as well as the bioavailability of pharmaceutical active compounds is the pharmacosomes which are formulated via complexation of drug molecules with phospholipids. Pharmacosomes are able to lower the interfacial tension between the developed system and the GIT fluid, thus facilitating the permeability of active agents through tissues, membranes, or cell walls; they are also capable of promoting the absorption of drugs across the biological barrier. Drug-phospholipid complexes are good alternatives used to improve bioavailability of drugs having low solubility or less permeability, and are also used for protection of active pharmaceutical agents from degradation in the gastrointestinal tract, reduction of gastrointestinal side effects of NSAIDs and other agents. The bitter taste of orally administered drugs is overcome by this approach, which also facilitates inhibition of P-GP (para-glycoprotein) efflux of the drugs.
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