Heterocyclic Compounds from Dehydroacetic Acid (DHA), and their Metal Complexes

Vikash Singh; Bhawna Pareek; Mayank Kinger; Vivek Sharma; Sushil Kumar

doi:10.70130/CAST.2022.5208

Authors

Vikash Singh Department of chemistry, Maharishi Markandeshwar (Deemed to be University) Mullana, Ambala Author
Bhawna Pareek Department of chemistry, Maharishi Markandeshwar (Deemed to be University) Mullana, Ambala Author
Mayank Kinger Chaudhary Bansi Lal University, Bhiwani Author
Vivek Sharma Department of chemistry, Maharishi Markandeshwar (Deemed to be University) Mullana, Ambala Author
Sushil Kumar Department of chemistry, Maharishi Markandeshwar (Deemed to be University) Mullana, Ambala Author

DOI:

https://doi.org/10.70130/CAST.2022.5208

Keywords:

DRUGS, DHA, HETEROCYCLIC COMPOUNDS, SCHIFF BASE LIGANDS, METAL COMPLEXES

Abstract

This study explores the synthetic versatility and biological relevance of heterocyclic compounds derived from dehydroacetic acid (DHA), a bioactive pyrone derivative. The reactivity of DHA with various nucleophiles—including hydrazines, amines, and Schiff base formers—has been leveraged to synthesize a diverse array of heterocyclic frameworks such as pyranopyrans, isoxazoles, pyranopyrazoles, pyrazolopyridones, benzimidazoles, and pyridones. Furthermore, the formation of metal complexes with these ligands, particularly involving transition metals like Cu(II), Ni(II), Co(II), Mn(II), and Zn(II), has been extensively investigated. These complexes were characterized and evaluated for their antibacterial, antifungal, anticancer, DNA-binding, and DNA-cleaving properties. Notably, Schiff base ligands exhibited enhanced bioactivity upon complexation, suggesting their potential as therapeutic agents. The catalytic potential of these metal complexes was also examined in oxidation, hydrogenation, and polymerization reactions, establishing DHA-based Schiff bases as multifunctional scaffolds in coordination chemistry and biomedical applications.

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