Unexplored Potential of Medicated Candies and Lozenges as a Drug Delivery System

Authors

  • Ankit Namdev Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar, India Author
  • Sumit Mishra Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar, India Author
  • Dharmendra Sharma Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar, India Author
  • Sourabh Soni Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar, India Author
  • Dharmendra Jain Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar, India Author

DOI:

https://doi.org/10.70130/CAST.2022.5104

Keywords:

LOZENGES, MEDICATED CANDY, ORAL DRUG DELIVERY, SWEETENERS, THROAT INFECTION

Abstract

 Candy formulation or Lozenges are types of solid dosage form which are considered as the divisions of tablets which slowly or gradually release the medicament in to the mouth over sustained period of time. They have prominent action in the local infections such as in the pharynx or mouth cavity infection but quite a few of lozenges are now being used systemically. Lozenges formulations are usually preferred for prominent candidate drug for first pass effect. Lozenges consist of different types of formulation such as chewable lozenges, hard lozenges, soft lozenges which have proven to be helpful for all categories of patients showing special compliance to the pediatric patients. Hard candy comprises uniform mixture of sugar (carbohydrates)especially sucrose in amorphous state. The present review covers more or less all aspects associated with lozenges and also deals with various applied concepts of them in treatment. Lozenges provide a palatable and compliable means of dosage form and have stamped its authority in pharmaceutical market owing to its several advantages, but it suffers from certain disadvantages too. The dosage form can be adopted for local as well as systemic therapy and a wide range of actives can be incorporated in them. 

References

Al-Nakib, W., Higgins, P. G., Barrow, I., Batstone, G., & Tyrrell, D. A. J. (1987). Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. Journal of Antimicrobial Chemotherapy, 20, 893-901.

Allen, L. V., & Erickson, M. A. (2009). Secundum artem. Current and practical compounding information for the pharmacist. Pharmaceutical Compounding Resources on the Internet, 10(1).

Dhumal, P. B., Nagoba, S. N., Ladde, S. S., & Rao, K. P. (2016). Formulation development and antimicrobial activity evaluation of medicated lozenges. World Journal of Pharmacy and Pharmaceutical Sciences, 5, 1599-1608.

Dineshmohan, S., Vanitha, K., Ramesh, A., Srikanth, G., & Akila, S. (2010). Formulation and evaluation of salbutamol sulphate fast dissolving tablet. International Journal of Research in Pharmaceutical and Biomedical Sciences, 1, 105-108.

Douglas, R. M., Miles, H. B., Moore, B. W., Ryan, P., & Pinnock, C. B. (1987). Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrobial Agents and Chemotherapy, 31, 1263-1265.

Eby, G. A., III. (2009). Zinc lozenges as cure for the common cold – A review and hypothesis. Medical Hypotheses, 74, 482–492.

Fouad, J., Bickel, W. K., & Bucci, L. R. (2011). In vitro investigation for embedding dextromethorphan in lipids using spray drying. Digest Journal of Nanomaterials and Biostructures, 6, 1129-1139.

Hooda, R. (2015). Research and reviews: Journal of Pharmacognosy and Phytochemistry. Journal of Pharmaceutical Research, 22-36.

Kamamia, E. K. (2013). Formulation development of orally retentive antimalarial lozenges for pediatric patients. Journal of Medical Research and Practice, 2, 197-202.

Kini, R., Rathnanand, M., & Kamath, D. (2011). Investigating the suitability of isomalt and liquid glucose as sugar substitute in the formulation of salbutamol sulfate hard candy lozenges. Journal of Chemical and Pharmaceutical Research, 3, 69-75.

Kumar, R., Solanki, P., & Chandra, A. (2014). Medicated chewing gum-A novel drug delivery system: An updated review. Open Journal of Advanced Drug Delivery, 2, 434-450.

Lakshmi, S. V. (2014). Medicated chewing gum: An overview. Research & Reviews: Journal of Dental Sciences, 2, 50-64.

Majekodunmi, S. O. (2015). A review on lozenges. American Journal of Medicine and Medical Sciences, 5, 99-104.

McQuillan, M., Heller, E., & Corver, M. (1995). The development of the UK market for intense and bulk sweeteners. British Food Journal, 97.

Patel, D. M., Patel, R. J., Shah, H. R., & Patel, C. N. (2014). Formulation and evaluation of diphenhydramine hydrochloride lozenges for treatment of cough. World Journal of Pharmacy and Pharmaceutical Sciences, 3, 822-34.

Pattnayak, D., Das, S., & Sahu, S. (2012). Formulation development and optimization of medicated lozenges for pediatric use. International Journal of Pharmaceutical Sciences and Research, 3, 138-140.

Petrus, E. J., Lawson, K. A., Bucci, L. R., & Blum, K. (1998). Randomized, double-masked, placebo-controlled clinical study of the effectiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects. Current Therapeutic Research, 59, 595-607.

Pothu, R., & Yamsani, M. R. (2014). Lozenges formulation and evaluation: A review. International Journal of Advances in Pharmaceutical Research, 5, 290-298.

Rao, K. P., Katti, G., Kartik, A., & Manjunath, P. (2013). Design of medicated lozenges for pediatrics. International Journal of Medical and Health Sciences, 2, 14-23.

Reddy, P. C., Chaitanya, K. S. C., & Rao, Y. M. (2011). A review on bioadhesive buccal drug delivery systems: Current status of formulation and evaluation methods. DARU Journal of Pharmaceutical Sciences, 19, 385-403.

Rehman, H., Zahoor, A., Shaikh, Z. A., Naveed, S., & Usmanghani, K. (2017). Polyherbal extract based Linkus lozenges for symptomatic relief: Design, development and evaluation. American Journal of Advanced Drug Delivery, 5.

Renuka, P., Shayeda, S., & Yamsani, M. R. (2014). Development and in-vitro evaluation of nicotine hard candy lozenges for smoking cessation. International Journal of Pharmacy and Pharmaceutical Sciences, 6, 625-629.

Rowe, R. C. (2002). Formulating fortunes–the tale of a medicated lozenge. Drug Discovery Today, 7, 286-287.

Schnoll, A. R., & Martinez, E. (2010). Nicotine patch vs. nicotine lozenges for smoking secession: An effective trial coordinated by the community clinical oncology program. Drug and Alcohol Dependence, 230-247.

Sharma, A., Rath, G. K., Chaudhary, S. P., Thakar, A., Mohanti, B. K., & Bahadur, S. (2012). Lactobacillus brevis CD2 lozenges reduce radiation-and chemotherapy-induced mucositis in patients with head and neck cancer: A randomized double-blind placebo-controlled study. European Journal of Cancer, 48, 875-881.

Shinde, S. G., Kadam, V., Kapse, G. R., & Jadhav, S. B. (2014). A review on lozenges. Indo American Journal of Pharmaceutical Research, 566-570.

Umashankar, M. S., Dinesh, S. R., Rini, R., Lakshmi, K. S., & Damodharan, N. (2016). Chewable lozenge formulation: A review. International Research Journal of Pharmacy, 7, 9-16.

Weismann, K. (1990). Zinc gluconate lozenges for common cold. Danish Medical Bulletin, 37, 279-81.

Witzler, J. J. P., Pinto, R. A., de Valdez, G. F., de Castro, A. D., & Cavallini, D. C. U. (2017). Development of a potential probiotic lozenge containing Enterococcus faecium CRL 183. LWT-Food Science and Technology, 77, 193-199.

Downloads

Published

2022-11-15

Issue

Section

Reviews

How to Cite

Namdev, A., Mishra, S., Sharma, D., Soni, S., & Jain, D. (2022). Unexplored Potential of Medicated Candies and Lozenges as a Drug Delivery System. Contemporary Advances in Science and Technology, 5(1), 41-62. https://doi.org/10.70130/CAST.2022.5104

Plaudit